Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and ori...
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Spindle orientation depends on the tethering of microtubules to the cell cortex through LGN, NuMA and dynein/dynactin. Cheeseman and colleagues find that spindle-pole-associated Plk1 activity restricts polar dynein whereas chromosomal RanGTP negatively regulates LGN localization at the lateral cell cortex, thus identifying two differentially locali...
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Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3290711
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3290711
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2440
