PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling
About this item
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Author / Creator
Shrestha, Y , Schafer, E J , Boehm, J S , Thomas, S R , He, F , Du, J , Wang, S , Barretina, J , Weir, B A , Zhao, J J , Polyak, K , Golub, T R , Beroukhim, R and Hahn, W C
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Activating mutations in the RAS family or
BRAF
frequently occur in many types of human cancers but are rarely detected in breast tumors. However, activation of the RAS–RAF–MEK–ERK MAPK pathway is commonly observed in human breast cancers, suggesting that other genetic alterations lead to activation of this signaling pathway. To identify breas...
Alternative Titles
Full title
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3291810
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3291810
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2011.515
