FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The Fanconi anemia pathway is involved in the signaling of DNA damage. Several Fanconi anemia proteins have been identified, but how the pathway is actually activated was unclear. Now, work on chicken DT40 cells indicates that phosphorylation of FANCI at multiple sites triggers FANCD2 monoubiquitination and DNA-damage repair.
In response to DNA...
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FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3293454
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3293454
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1504
