Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/C...
Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms
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Author / Creator
Francis, Heather L , DeMorrow, Sharon , Franchitto, Antonio , Venter, Julie K , Mancinelli, Romina A , White, Mellanie A , Meng, Fanyin , Ueno, Yoshiyuki , Carpino, Guido , Renzi, Anastasia , Baker, Kimberly K , Shine, Hannah E , Francis, Taylor C , Gaudio, Eugenio , Alpini, Gianfranco D and Onori, Paolo
Publisher
New York: Elsevier Inc
Journal title
Language
English
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Publisher
New York: Elsevier Inc
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Scope and Contents
Contents
Although large cholangiocytes exert their functions by activation of cyclic adenosine 3′,5′-monophosphate (cAMP), Ca2+-dependent signaling regulates the function of small cholangiocytes. Histamine interacts with four receptors, H1–H4HRs. H1HR acts by Gαq activating IP3/Ca2+, whereas H2HR activates Gαs stimulating cAMP. We hypothesize that histamine...
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Full title
Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3293651
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3293651
Other Identifiers
ISSN
0023-6837
E-ISSN
1530-0307
DOI
10.1038/labinvest.2011.158
