Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c⁺...
Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c⁺ CD11b⁺ dendritic cells
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Development of type 1 diabetes in the nonobese diabetic (NOD) mouse is preceded by an immune cell infiltrate in the pancreatic islets. The exact role of the attracted cells is still poorly understood. Chemokine CCL2/MCP-1 is known to attract CCR2⁺ monocytes and dendritic cells (DCs). We have previously shown that transgenic expression of CCL2 in pa...
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Full title
Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c⁺ CD11b⁺ dendritic cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3295274
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3295274
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1115308109
