Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather th...
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly
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Author / Creator
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
Respiratory chain (RC) complexes are organized into supercomplexes forming ‘respirasomes’. The mechanism underlying the interdependence of individual complexes is still unclear. Here, we show in human patient cells that the presence of a truncated COX1 subunit leads to destabilization of complex IV (CIV) and other RC complexes. Surprisingly, the tr...
Alternative Titles
Full title
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3297988
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3297988
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2011.477
