Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resis...
Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
About this item
Full title
Author / Creator
Talbot, Konrad , Wang, Hoau-Yan , Kazi, Hala , Han, Li-Ying , Bakshi, Kalindi P. , Stucky, Andres , Fuino, Robert L. , Kawaguchi, Krista R. , Samoyedny, Andrew J. , Wilson, Robert S. , Arvanitakis, Zoe , Schneider, Julie A. , Wolf, Bryan A. , Bennett, David A. , Trojanowski, John Q. and Arnold, Steven E.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder. We provide such a demonstration here by showing that the hippocampal formation (HF) and, to a lesser degree, the cerebellar cortex in AD cases without diabetes exhibit markedly reduced responses to insulin signa...
Alternative Titles
Full title
Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3314463
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3314463
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI59903
