Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
A family of small molecules called ‘ciliobrevins’ are described that can rapidly and reversibly modulate the AAA+ ATPase motor dynein, which transports cargo molecules along microtubule tracks.
Ciliobrevins inhibit dynein motor protein
Enzymes of the AAA+ ATPase family convert chemical potential energy into the mechanical forces required for...
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Full title
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3321072
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3321072
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10936
