Mice Lacking DNA Topoisomerase IIIβ Develop to Maturity but Show a Reduced Mean Lifespan
Mice Lacking DNA Topoisomerase IIIβ Develop to Maturity but Show a Reduced Mean Lifespan
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Publisher
National Academy of Sciences
Journal title
Language
English
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Publisher
National Academy of Sciences
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Contents
Targeted gene disruption in the murine TOP3β gene-encoding DNA topoisomerase IIIβ was carried out. In contrast to the embryonic lethality of mutant mice lacking DNA topoisomerase IIIα, top3 β-/- nulls are viable and grow to maturity with no apparent defects. Mice lacking DNA topoisomerase IIIβ have a shorter life expectancy than their wild-type lit...
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Full title
Mice Lacking DNA Topoisomerase IIIβ Develop to Maturity but Show a Reduced Mean Lifespan
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_33279
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_33279
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.101132498
