Hexavalent Chromium Cr(VI) Up-Regulates COX-2 Expression through an NFκB/c-Jun/AP-1–Dependent Pathwa...
Hexavalent Chromium Cr(VI) Up-Regulates COX-2 Expression through an NFκB/c-Jun/AP-1–Dependent Pathway
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Research Triangle Park, NC: National Institute of Environmental Health Sciences
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Language
English
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Research Triangle Park, NC: National Institute of Environmental Health Sciences
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Background: Hexavalent chromium [Cr(VI)] is recognized as a human carcinogen via inhalation. However, the molecular mechanisms by which Cr(VI) causes cancers are not well understood. Objectives: We evaluated cyclooxygenase-2 (COX-2) expression and the signaling pathway leading to this induction due to Cr(VI) exposure in cultured cells. Methods: We...
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Full title
Hexavalent Chromium Cr(VI) Up-Regulates COX-2 Expression through an NFκB/c-Jun/AP-1–Dependent Pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3339461
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3339461
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ISSN
0091-6765,1552-9924
E-ISSN
1552-9924
DOI
10.1289/ehp.1104179
