IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
About this item
Full title
Author / Creator
Turcan, Sevin , Rohle, Daniel , Goenka, Anuj , Walsh, Logan A. , Fang, Fang , Yilmaz, Emrullah , Campos, Carl , Fabius, Armida W. M. , Lu, Chao , Ward, Patrick S. , Thompson, Craig B. , Kaufman, Andrew , Guryanova, Olga , Levine, Ross , Heguy, Adriana , Viale, Agnes , Morris, Luc G. T. , Huse, Jason T. , Mellinghoff, Ingo K. and Chan, Timothy A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutation of isocitrate dehydrogenase 1 (IDH1) is shown to induce DNA hypermethylation and to remodel the epigenome to resemble that of gliomas with the CpG island methylator phenotype.
Cancer induction by isocitrate dehydrogenase mutation
Mutations in the isocitrate dehydrogenase genes
IDH1
and
IDH2
have been identified in gliomas...
Alternative Titles
Full title
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Authors, Artists and Contributors
Author / Creator
Rohle, Daniel
Goenka, Anuj
Walsh, Logan A.
Fang, Fang
Yilmaz, Emrullah
Campos, Carl
Fabius, Armida W. M.
Lu, Chao
Ward, Patrick S.
Thompson, Craig B.
Kaufman, Andrew
Guryanova, Olga
Levine, Ross
Heguy, Adriana
Viale, Agnes
Morris, Luc G. T.
Huse, Jason T.
Mellinghoff, Ingo K.
Chan, Timothy A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3351699
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3351699
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10866
