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Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility s...

Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility s...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3362594

Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility study

About this item

Full title

Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility study

Publisher

Greece: D.A. Spandidos

Journal title

Oncology letters, 2012-01, Vol.3 (1), p.89-93

Language

English

Formats

Publication information

Publisher

Greece: D.A. Spandidos

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Irinotecan hydrochloride (CPT-11) is reported to be involved in the downregulation of thymidylate synthase (TS), a target molecule of 5-fluorouracil (5-FU) and oral fluoropyrimidine S-1. Therefore, we hypothesized that a preceding administration of CPT-11 against S-1-resistant tumors may recover sensitivity to S-1. To this end, we planned a S-1/CPT...

Alternative Titles

Full title

Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility study

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3362594

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3362594

Other Identifiers

ISSN

1792-1074

E-ISSN

1792-1082

DOI

10.3892/ol.2011.435

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