S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A molecular switch for eNOS
The enzyme eNOS (endothelial nitric oxide synthase) is vital for regulating vascular function as it can produce both the vasodilator nitric oxide and the vasoconstrictor superoxide. Jay Zweier and colleagues show that a modification associated with oxidant stress, S-glutathionylation, switches the enzyme from forming...
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S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3370391
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3370391
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0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature09599