Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interactio...
Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Inactivation of the retinoblastoma protein (pRb) by phosphorylation triggers uncontrolled cell proliferation. Accordingly, activation of cyclin-dependent kinase (CDK)/cyclin complexes or downregulation of CDK inhibitors appears as a common event in human cancer. Here we show that Pin1 (protein interacting with NIMA (never in mitosis A)-1), a peptid...
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Full title
Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3374078
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3374078
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2011.202
