Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Scope and Contents
Contents
Notch, a molecule widely known for its role in development and cancer, regulates hepatic glucose metabolism by offsetting excessive glucose production. Given that a series of Notch antagonists are in clinical trials against cancer, they could also be useful against type 2 diabetes.
Transcription factor FoxO1 promotes hepatic glucose production....
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Full title
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3387563
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3387563
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2378
