Biophysical mechanism of T-cell receptor triggering in a reconstituted system
Biophysical mechanism of T-cell receptor triggering in a reconstituted system
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Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
A T-cell-mediated immune response is initiated by the T-cell receptor (TCR) interacting with peptide-bound major histocompatibility complex (pMHC) on an infected cell. The mechanism by which this interaction triggers intracellular phosphorylation of the TCR, which lacks a kinase domain, remains poorly understood. Here, we have introduced the TCR an...
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Full title
Biophysical mechanism of T-cell receptor triggering in a reconstituted system
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3393772
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3393772
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11220
