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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3401912

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

About this item

Full title

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Publisher

London: Nature Publishing Group UK

Journal title

Nature reviews. Cancer, 2012-01, Vol.12 (1), p.9-22

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Key Points
Hypoxia-inducible factor 1α (HIF1α) and HIF2α are broadly expressed in many human cancers, and expression of these proteins frequently correlate with poor patient prognosis.
Although HIF1α and HIF2α share some redundant functions, they also exhibit unique and even opposing activities in cell growth, metabolism, angiogenesis, nitric...

Alternative Titles

Full title

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3401912

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3401912

Other Identifiers

ISSN

1474-175X

E-ISSN

1474-1768

DOI

10.1038/nrc3183

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