Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling
About this item
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Author / Creator
Yu, Yu , Wu, Junzhou , Wang, Yunling , Zhao, Ting , Ma, Bo , Liu, Yuqing , Fang, Weigang , Zhu, Wei-Guo and Zhang, Hongquan
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
Kindlin 2, as a focal adhesion protein, controls integrin activation. However, the association of Kindlin 2 with cancer‐related signalling pathways is unknown. Here we identified a new direct interaction between Kindlin 2 and the active β‐catenin. Importantly, Kindlin 2 forms a tripartite complex with β‐catenin and TCF4. Mechanistically, Kindlin 2...
Alternative Titles
Full title
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3410388
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3410388
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2012.88
