Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
About this item
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Author / Creator
Perez, Elena E , Wang, Jianbin , Miller, Jeffrey C , Jouvenot, Yann , Kim, Kenneth A , Liu, Olga , Wang, Nathaniel , Lee, Gary , Bartsevich, Victor V , Lee, Ya-Li , Guschin, Dmitry Y , Rupniewski, Igor , Waite, Adam J , Carpenito, Carmine , Carroll, Richard G , S Orange, Jordan , Urnov, Fyodor D , Rebar, Edward J , Ando, Dale , Gregory, Philip D , Riley, James L , Holmes, Michael C and June, Carl H
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Homozygosity for the naturally occurring
Δ32
deletion in the HIV co-receptor
CCR5
confers resistance to HIV-1 infection. We generated an HIV-resistant genotype
de novo
using engineered zinc-finger nucleases (ZFNs) to disrupt endogenous
CCR5
. Transient expression of CCR5 ZFNs permanently and specifically disrupted ∼50% of
Alternative Titles
Full title
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Authors, Artists and Contributors
Author / Creator
Wang, Jianbin
Miller, Jeffrey C
Jouvenot, Yann
Kim, Kenneth A
Liu, Olga
Wang, Nathaniel
Lee, Gary
Bartsevich, Victor V
Lee, Ya-Li
Guschin, Dmitry Y
Rupniewski, Igor
Waite, Adam J
Carpenito, Carmine
Carroll, Richard G
S Orange, Jordan
Urnov, Fyodor D
Rebar, Edward J
Ando, Dale
Gregory, Philip D
Riley, James L
Holmes, Michael C
June, Carl H
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3422503
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3422503
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt1410
