AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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AID/APOBEC deaminases, which convert cytosine bases to uracils in DNA and RNA, have recently been assigned a role in epigenetic regulation as components of DNA demethylation pathways. A systematic study shows that AID/APOBEC enzymes preferentially deaminate unmodified cytosine over its C5-modified forms, calling into question the plausibility of de...
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AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3427411
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3427411
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1042
