LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
The linear ubiquitin chain assembly complex (LUBAC) is a RING E3 ligase that regulates immune and inflammatory signalling pathways. Unlike classical RING E3 ligases, LUBAC determines the type of ubiquitin chain being formed, an activity normally associated with the E2 enzyme. We show that the RING‐in‐between‐RING (RBR)‐containing region of HOIP—the...
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Full title
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3432797
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3432797
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2012.105
