Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia
Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia
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Basingstoke: Nature Publishing Group
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English
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Basingstoke: Nature Publishing Group
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Contents
Major depression is associated with both dysregulated glutamatergic neurotransmission and fewer astrocytes in limbic areas including the prefrontal cortex (PFC). These deficits may be functionally related. Notably, astrocytes regulate glutamate levels by removing glutamate from the synapse via the glutamate transporter (GLT-1). Previously, we demon...
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Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3442341
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3442341
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ISSN
0893-133X
E-ISSN
1740-634X
DOI
10.1038/npp.2012.105
