2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of C...
2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε
About this item
Full title
Author / Creator
Publisher
Vienna: Springer Vienna
Journal title
Language
English
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Publication information
Publisher
Vienna: Springer Vienna
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More information
Scope and Contents
Contents
In this study we identified two heterocyclic compounds (
5
and
6
) as potent and specific inhibitors of CK1δ (IC
50
= 0.040 and 0.042 μM, respectively). Whereas compound
5
exhibited fivefold higher affinity towards CK1δ than to CK1ε (IC
50
CK1ε = 0.199 μM), compound
6
also inhibited CK1ε (IC
50
= 0.0326 μ...
Alternative Titles
Full title
2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3448056
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3448056
Other Identifiers
ISSN
0939-4451
E-ISSN
1438-2199
DOI
10.1007/s00726-012-1234-x
