Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses
Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Lrp4 acts bidirectionally and coordinates synapse formation by binding agrin, activating MuSK and stimulating postsynaptic differentiation, and functioning in turn as a muscle-derived retrograde signal that is necessary and sufficient for presynaptic differentiation.
Neuromuscular junctions send wrong signals
Developing neuromuscular junction...
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Full title
Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3448831
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3448831
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11348
