SOX2 regulates the hypothalamic-pituitary axis at multiple levels
SOX2 regulates the hypothalamic-pituitary axis at multiple levels
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Sex-determining region Y (SRY) box 2 (SOX2) haploinsufficiency causes a form of hypopituitarism in humans that is characterized by gonadotrophin deficiency known as hypogonadotrophic hypogonadism. Here, we conditionally deleted Sox2 in mice to investigate the pathogenesis of hypogonadotrophic hypogonadism. First, we found that absence of SOX2 in th...
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Full title
SOX2 regulates the hypothalamic-pituitary axis at multiple levels
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3461924
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3461924
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI64311
