The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocycl...
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The subtilisin-like domain of PatG can catalyze the macrocyclization of linear peptide. The crystal structure of the PatG macrocyclase domain, along with mutagenesis and functional analyses, reveals how the enzyme recognizes its substrate and enforces macrocyclization over hydrolysis of the acyl-enzyme intermediate. This information is also used to...
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Full title
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3462482
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3462482
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.2340
