Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein c...
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The eight metabotropic glutamate receptors (mGluRs) are key modulators of synaptic transmission and are considered promising targets for the treatment of various brain disorders. Whereas glutamate acts at a large extracellular domain, allosteric modulators have been identified that bind to the seven transmembrane domain (7TM) of these dimeric G-pro...
Alternative Titles
Full title
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3479612
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3479612
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1205838109
