Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In humans, PGRN haploinsufficiency is a major inherited cause of frontotemporal dementia (FTD), but how PGRN deficiency causes neurodegeneration is unknown. Here we show that loss of PGRN results in increased neuron loss in response to injury in the CNS. When...
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Full title
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3484443
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3484443
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI63113
