Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer
About this item
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Author / Creator
Kämpjärvi, K , Mäkinen, N , Kilpivaara, O , Arola, J , Heinonen, H-R , Böhm, J , Abdel-Wahab, O , Lehtonen, H J , Pelttari, L M , Mehine, M , Schrewe, H , Nevanlinna, H , Levine, R L , Hokland, P , Böhling, T , Mecklin, J-P , Bützow, R , Aaltonen, L A and Vahteristo, P
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Background:
Mediator complex participates in transcriptional regulation by connecting regulatory DNA sequences to the RNA polymerase II initiation complex. Recently, we discovered through exome sequencing that as many as 70% of uterine leiomyomas harbour specific mutations in exon 2 of
mediator complex subunit 12
(
MED12
). In this w...
Alternative Titles
Full title
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3493861
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3493861
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/bjc.2012.428
