β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell–cell junctions by differ...
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell–cell junctions by differentially regulating Tiam1 activity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Although Rac and its activator Tiam1 are known to stimulate cell–cell adhesion, the mechanisms regulating their activity in cell–cell junction formation are poorly understood. Here, we identify β2-syntrophin as a Tiam1 interactor required for optimal cell–cell adhesion. We show that during tight-junction (TJ) assembly β2-syntrophin promotes Tiam1–R...
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β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell–cell junctions by differentially regulating Tiam1 activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3498067
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3498067
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1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/ncb2608
