Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor
Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The interaction between IgE and its receptor FcεRI underlies many allergic responses; here the structure and mechanism of a newly engineered DARPin inhibitor is presented, revealing that it not only blocks the receptor–ligand interaction but also dissociates already-formed complexes.
An anti-IgE DARPin–Fc complex dissected
The interaction bet...
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Full title
Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3504642
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3504642
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11546
