Fibrinogen-induced perivascular microglial clustering is required for the development of axonal dama...
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
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Author / Creator
Davalos, Dimitrios , Kyu Ryu, Jae , Merlini, Mario , Baeten, Kim M. , Le Moan, Natacha , Petersen, Mark A. , Deerinck, Thomas J. , Smirnoff, Dimitri S. , Bedard, Catherine , Hakozaki, Hiroyuki , Gonias Murray, Sara , Ling, Jennie B. , Lassmann, Hans , Degen, Jay L. , Ellisman, Mark H. and Akassoglou, Katerina
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of multiple sclerosis. However, the initial triggers that activate innate immune responses and their role in axonal damage remain unknown. Here we show that the blood protein fibrinogen induces rapid microglial responses toward the vasculature and is required...
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Full title
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3514498
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3514498
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/ncomms2230
