Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
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Author / Creator
BECK JORGENSEN, Sebastian , O'NEILL, Hayley M , DER POEL, Chris Van , TROUNCE, Ian A , LYNCH, Gordon S , SCHERTZER, Jonathan D , STEINBERG, Gregory R , SYLOW, Lykke , HONEYMAN, Jane , HEWITT, Kimberly A , PALANIVEL, Rengasamy , FULLERTON, Morgan D , ÖBERG, Lisa , BALENDRAN, Anudharan and GALIC, Sandra
Publisher
Alexandria, VA: American Diabetes Association
Journal title
Language
English
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Publication information
Publisher
Alexandria, VA: American Diabetes Association
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Scope and Contents
Contents
Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin signal transduction in adipose tissue and the liver....
Alternative Titles
Full title
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3526029
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3526029
Other Identifiers
ISSN
0012-1797
E-ISSN
1939-327X
DOI
10.2337/db12-0443
