Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Klotho is a membrane protein predominantly produced in the kidney that exerts some antiageing effects. Ageing is associated with an increased risk of heart failure; whether Klotho is cardioprotective is unknown. Here we show that Klotho-deficient mice have no baseline cardiac abnormalities but develop exaggerated pathological cardiac hypertrophy an...
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Full title
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3526952
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3526952
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms2240
