Log in to save to my catalogue
Log in to save to my catalogue

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

| Ask | Become a Library member

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3527075

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

About this item

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Neurons and oligodendrocytes differentiated from induced pluripotent stem cells (iPSCs) of patients with inherited TLR3 and UNC-93B deficiencies are found to be more susceptible to infection by HSV-1 than control cells because they fail to induce a normal interferon response, whereas neural stem cells and astrocytes are not susceptible.
Paediatr...

Alternative Titles

Full title

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3527075

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3527075

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature11583

How to access this item

Log in as a Library member

View record in Gale

About resource

About resource

About resource

View in old catalogue

Connecting people and collections