Multi-cell type human liver microtissues for hepatotoxicity testing
Multi-cell type human liver microtissues for hepatotoxicity testing
About this item
Full title
Author / Creator
Messner, S. , Agarkova, I. , Moritz, W. and Kelm, J. M.
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer-Verlag
Subjects
More information
Scope and Contents
Contents
Current 2-dimensional hepatic model systems often fail to predict chemically induced hepatotoxicity due to the loss of a hepatocyte-specific phenotype in culture. For more predictive in vitro models, hepatocytes have to be maintained in a 3-dimensional environment that allows for polarization and cell–cell contacts. Preferably, the model will refle...
Alternative Titles
Full title
Multi-cell type human liver microtissues for hepatotoxicity testing
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3535351
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3535351
Other Identifiers
ISSN
0340-5761
E-ISSN
1432-0738
DOI
10.1007/s00204-012-0968-2
