Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in S...
Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
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New York: Humana Press Inc
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Language
English
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New York: Humana Press Inc
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Amyloid precursor protein cleavage through β- and γ-secretases produces β-amyloid peptide, which is believed to be responsible for death of neurons and dementia in Alzheimer’s disease. Levels of β- and γ-secretase are increased in sensitive areas of the Alzheimer’s disease brain, but the mechanism of this process is unknown. In this review, we prov...
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Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3538125
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3538125
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ISSN
0893-7648
E-ISSN
1559-1182
DOI
10.1007/s12035-012-8360-z
