Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimenta...
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant, and Nec-1 stable (Nec-1s), its more stable variant. We report that Nec...
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Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3542611
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3542611
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2012.176
