Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Paneth cells carve out a niche
Paneth cells, specialized cells found in the intestinal epithelium, are known to protect stem cells by producing bactericidal compounds. Now another crucial function is reported: they provide the essential niche signals (EGF/TGFα, Notch and Wnt) for
Lgr5
-expressing stem cells in the small intestine. Multipot...
Alternative Titles
Full title
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3547360
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3547360
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature09637
