Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
About this item
Full title
Author / Creator
Jacobetz, Michael A , Chan, Derek S , Neesse, Albrecht , Bapiro, Tashinga E , Cook, Natalie , Frese, Kristopher K , Feig, Christine , Nakagawa, Tomoaki , Caldwell, Meredith E , Zecchini, Heather I , Lolkema, Martijn P , Jiang, Ping , Kultti, Anne , Thompson, Curtis B , Maneval, Daniel C , Jodrell, Duncan I , Frost, Gregory I , Shepard, H M , Skepper, Jeremy N and Tuveson, David A
Publisher
London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
Formats
Publication information
Publisher
London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Subjects
More information
Scope and Contents
Contents
Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan (HA), as a novel therapeutic target in PDA. Methods Using a genetically engi...
Alternative Titles
Full title
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Authors, Artists and Contributors
Author / Creator
Chan, Derek S
Neesse, Albrecht
Bapiro, Tashinga E
Cook, Natalie
Frese, Kristopher K
Feig, Christine
Nakagawa, Tomoaki
Caldwell, Meredith E
Zecchini, Heather I
Lolkema, Martijn P
Jiang, Ping
Kultti, Anne
Thompson, Curtis B
Maneval, Daniel C
Jodrell, Duncan I
Frost, Gregory I
Shepard, H M
Skepper, Jeremy N
Tuveson, David A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3551211
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3551211
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2012-302529
