Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins
Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins
About this item
Full title
Author / Creator
Bugni, J M , Meira, L B and Samson, L D
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
O
6
-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including nearly half of sporadic colorectal cancers, suggesting that this loss maybe causal. Using mice with a targeted disruption of the
Mgmt...
Alternative Titles
Full title
Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3557788
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3557788
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2008.426
