Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
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Author / Creator
Mao, Kairui , Chen, Shuzhen , Chen, Mingkuan , Ma, Yonglei , Wang, Yan , Huang, Bo , He, Zhengyu , Zeng, Yan , Hu, Yu , Sun, Shuhui , Li, Jing , Wu, Xiaodong , Wang, Xiangrui , Strober, Warren , Chen, Chang , Meng, Guangxun and Sun, Bing
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β （IL-1β）, yet the regulation of these complexes remains poorly characterized. Here we show that nitric oxide （NO） inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1β secretion in myeloid cells fro...
Alternative Titles
Full title
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3567828
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3567828
Other Identifiers
ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2013.6
