T-cell death following immune activation is mediated by mitochondria-localized SARM
T-cell death following immune activation is mediated by mitochondria-localized SARM
About this item
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Author / Creator
Panneerselvam, P , Singh, L P , Selvarajan, V , Chng, W J , Ng, S B , Tan, N S , Ho, B , Chen, J and Ding, J L
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile
α
- and heat armadillo-motif-containing protein (SARM), the most conserved Toll-like receptors adaptor, is proapoptotic during T-cell immune response....
Alternative Titles
Full title
T-cell death following immune activation is mediated by mitochondria-localized SARM
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3569988
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3569988
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2012.144
