Abraxas and Rap80 form a novel BRCA1 protein complex required for the DNA damage response
Abraxas and Rap80 form a novel BRCA1 protein complex required for the DNA damage response
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English
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The BRCT repeats of BRCA1 are essential for tumor suppression. Phospho-peptide affinity proteomic analysis identified a novel protein, Abraxas, that directly binds the BRCA1 BRCT repeats through a phospho-SXXF motif. Abraxas binds BRCA1 mutually exclusively with BACH1 and CTIP, forming a third Brca1 complex. Abraxas recruits the ubiquitin-interacti...
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Abraxas and Rap80 form a novel BRCA1 protein complex required for the DNA damage response
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3573690
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3573690
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1139476
