Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor
Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor
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Author / Creator
OKAMOTO, KIYOSHI , ITO, DAISUKE , MIYAZAKI, KAZUKI , WATANABE, SAORI , TOHYAMA, OSAMU , YOKOI, AKIRA , OZAWA, YOICHI , ASANO, MAKOTO , KAWAMURA, TAKANORI , YAMANE, YOSHINOBU , NAGAO, SATOSHI , FUNASAKA, SETSUO , KAMATA, JUNICHI , KOTAKE, YOSHIHIKO , AOKI, MIKA , TSUKAHARA, NAOKO , MIZUI, YOSHIHARU , TANAKA, ISAO and SAWADA, KOHEI
Publisher
D.A. Spandidos
Journal title
Language
English
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Publication information
Publisher
D.A. Spandidos
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Scope and Contents
Contents
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that play crucial roles in the adaptation of cancer cells to hypoxia. HIF-1α overexpression has been associated with poor prognosis in patients with various types of cancer. Here, we describe ER-400583-00 as a novel HIF-1 inhibitor. ER-400583-00 suppressed the production of HIF...
Alternative Titles
Full title
Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3577141
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3577141
Other Identifiers
ISSN
1107-3756
E-ISSN
1791-244X
DOI
10.3892/ijmm.2011.875
