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TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589141

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

About this item

Full title

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2012-10, Vol.122 (10), p.3563-3578

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

The strength and duration of NF-κB signaling are tightly controlled by multiple negative feedback mechanisms. However, in cancer cells, these feedback loops are overridden through unclear mechanisms to sustain oncogenic activation of NF-κB signaling. Previously, we demonstrated that overexpression of miR-30e* directly represses IκBα expression and...

Alternative Titles

Full title

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589141

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589141

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI62339

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