Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing
Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing
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Author / Creator
Lu, Sijia , Zong, Chenghang , Fan, Wei , Yang, Mingyu , Li, Jinsen , Chapman, Alec R. , Zhu, Ping , Hu, Xuesong , Xu, Liya , Yan, Liying , Bai, Fan , Qiao, Jie , Tang, Fuchou , Li, Ruiqiang and Xie, X. Sunney
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
Meiotic recombination creates genetic diversity and ensures segregation of homologous chromosomes. Previous population analyses yielded results averaged among individuals and affected by evolutionary pressures. We sequenced 99 sperm from an Asian male by using the newly developed amplification method—multiple annealing and looping-based amplificati...
Alternative Titles
Full title
Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3590491
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3590491
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1229112
