Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu2...
Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease
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Author / Creator
Vélez, J I , Chandrasekharappa, S C , Henao, E , Martinez, A F , Harper, U , Jones, M , Solomon, B D , Lopez, L , Garcia, G , Aguirre-Acevedo, D C , Acosta-Baena, N , Correa, J C , Lopera-Gómez, C M , Jaramillo-Elorza, M C , Rivera, D , Kosik, K S , Schork, N J , Swanson, J M , Lopera, F and Arcos-Burgos, M
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such large cohorts, we describe here...
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Full title
Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3596442
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3596442
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/mp.2012.81
