Allosteric inhibition of hypoxia inducible factor-2 with small molecules
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
A new small-molecule inhibitor that selectively binds an internal cavity in HIF-2α allosterically disrupts HIF-2α–ARNT interaction
in vitro
and in cells. This compound should allow scientists to interrogate HIF-2α's activity in hypoxia and cancer cells.
Hypoxia inducible factors (HIFs) are heterodimeric transcription factors induced in man...
Alternative Titles
Full title
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3604136
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3604136
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1185
