Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for...
Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor
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Full title
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Publisher
United States: American Diabetes Association
Journal title
Language
English
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Publication information
Publisher
United States: American Diabetes Association
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Scope and Contents
Contents
Glucagon is a critical regulator of glucose homeostasis; however, mechanisms regulating glucagon action and α-cell function and number are incompletely understood. To elucidate the role of the hepatic glucagon receptor (Gcgr) in glucagon action, we generated mice with hepatocyte-specific deletion of the glucagon receptor. Gcgr(Hep)(-/-) mice exhibi...
Alternative Titles
Full title
Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3609565
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3609565
Other Identifiers
ISSN
0012-1797
E-ISSN
1939-327X
DOI
10.2337/db11-1605
